Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 4/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 10/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.59 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | PAK4 | O96013 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31684761 | 1.00 | MAP3K7 (0.65) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL28980964 | 0.90 | MAP3K7 (0.72) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL31684799 | 0.90 | MAP3K7 (0.72) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL30905170 | 0.88 | SLC2A1 (0.62) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL28980972 | 0.88 | MAP3K7 (0.67) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL28980991 | 0.88 | MAP3K7 (0.70) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL31684798 | 0.88 | MAP3K7 (0.67) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL31684780 | 0.88 | MAP3K7 (0.70) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL31684777 | 0.88 | MAP3K7 (0.80) | MAP3K7ALKFGFR1MAP2K1SRC | |
| SCHEMBL28980982 | 0.88 | MAP3K7 (0.80) | MAP3K7ALKFGFR1MAP2K1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | claimed |
| CN-115894381-A | 2,4,5-trisubstituted pyrimidine compound and preparation method and application thereof | 温州医科大学 | 2023-04-04 | — | — | CN | disclosed |