Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.33 |
| ▸ | JAK1 | P23458 | 7/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28982168 | 1.00 | JAK2 (0.33) | JAK2JAK1TBK1P2RX3TTK | |
| SCHEMBL28982229 | 0.94 | JAK2 (0.35) | JAK2JAK1TBK1TTKPTK6 | |
| SCHEMBL28982227 | 0.94 | JAK2 (0.35) | JAK2JAK1TBK1TTKPTK6 | |
| SCHEMBL25176001 | 0.94 | — | — | |
| SCHEMBL22123534 | 0.91 | PTK6 (0.33) | JAK2JAK1TTKPTK6 | |
| SCHEMBL22123535 | 0.91 | PTK6 (0.33) | JAK2JAK1TTKPTK6 | |
| Iodide SCHEMBL25175987 | 0.91 | TBK1 (0.32) | JAK2JAK1TBK1 | |
| Iodide SCHEMBL25175988 | 0.91 | TBK1 (0.32) | JAK2JAK1TBK1 | |
| SCHEMBL30385397 | 0.90 | JAK2 (0.35) | JAK2JAK1TBK1TYK2JAK3 | |
| SCHEMBL30385462 | 0.90 | CYP2C9 (0.34) | JAK2JAK1TBK1P2RX3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115916784-A | Novel imidazopyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-04-04 | — | — | CN | disclosed |