Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 8/20 | 0.33 |
| ▸ | JAK1 | P23458 | 8/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30385630 | 0.94 | GPR119 (0.37) | JAK2JAK1ADORA2AADORA2BLMNA | |
| SCHEMBL28982171 | 0.93 | JAK2 (0.33) | P2RX3JAK2JAK1TYK2JAK3 | |
| SCHEMBL30385397 | 0.92 | JAK2 (0.35) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL30385548 | 0.91 | JAK2 (0.34) | JAK2JAK1LMNATP53GPR119 | |
| SCHEMBL30385420 | 0.90 | P2RX3 (0.33) | P2RX3JAK2JAK1TYK2JAK3 | |
| Iodide SCHEMBL25170358 | 0.90 | CYP2C9 (0.33) | CYP2C9P2RX3JAK2JAK1TYK2 | |
| SCHEMBL28982170 | 0.90 | JAK2 (0.33) | P2RX3JAK2JAK1TYK2JAK3 | |
| SCHEMBL28982168 | 0.90 | JAK2 (0.33) | P2RX3JAK2JAK1TYK2JAK3 | |
| SCHEMBL30385499 | 0.89 | TP53 (0.38) | JAK2JAK1TYK2JAK3LMNA | |
| SCHEMBL30385560 | 0.89 | PTK6 (0.35) | P2RX3JAK2JAK1TBK1PTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161931-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-12 | — | — | EP | disclosed |