Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616695 | 0.82 | ALDH1A1 (0.42) | KDM4E | |
| SCHEMBL1616597 | 0.81 | MAP2K4 (0.38) | KDM4EPFKFB3 | |
| SCHEMBL1615349 | 0.80 | MAP2K4 (0.38) | KDM4EPFKFB3 | |
| SCHEMBL2243192 | 0.80 | ACHE (0.42) | KDM4EHTR1AMCHR1PFKFB3 | |
| SCHEMBL1615734 | 0.77 | PFKFB3 (0.39) | KDM4EPFKFB3 | |
| SCHEMBL1615961 | 0.76 | KDM4E (0.34) | KDM4EMCHR1 | |
| SCHEMBL2905912 | 0.73 | MCHR1 (0.39) | HTR1AMCHR1PFKFB3 | |
| SCHEMBL1615706 | 0.72 | METAP2 (0.38) | KDM4E | |
| SCHEMBL2243251 | 0.71 | MEN1 (0.41) | — | |
| SCHEMBL1615576 | 0.70 | CA1 (0.38) | KDM4EPFKFB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099763-B1 | 2-AMINOQUINOLINES AS 5-HT(5A) RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | claimed |