SCHEMBL28985000

SCHEMBL28985000

COC(c1ccc(-c2ccccc2)cc1)C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.42
PTGS2 P35354 1/20 0.40
EPHX1 P07099 1/20 0.39
CHRNB2 P17787 1/20 0.38
CHRNA4 P43681 1/20 0.38
NPSR1 Q6W5P4 2/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
GAA P10253 1/20 0.36
ACP3 P15309 1/20 0.36
PTPN5 P54829 1/20 0.36
MAPK1 P28482 1/20 0.35
MLKL Q8NB16 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12199965 0.88 NPSR1 (0.43) EPHX1NPSR1L3MBTL1GAAMAPK1
SCHEMBL12199974 0.88 NPSR1 (0.43) EPHX1NPSR1L3MBTL1GAAMAPK1
SCHEMBL7715366 0.88 NPSR1 (0.43) EPHX1NPSR1L3MBTL1GAAMAPK1
SCHEMBL28961301 0.85 KIF11 (0.39) KIF11PTGS2EPHX1CHRNB2CHRNA4
SCHEMBL28985017 0.83 KIF11 (0.45) KIF11
SCHEMBL28985275 0.80 CTSL (0.38)
SCHEMBL28985020 0.80 KIF11 (0.44) KIF11
SCHEMBL12282035 0.78 CHRNA7 (0.37) KIF11NPSR1L3MBTL1GAAMAPK1
SCHEMBL12282257 0.78 AOC3 (0.42)
SCHEMBL28985015 0.78 CYP2A6 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115948752-A Reaction method for selective fluorination functionalization of harmonious difluoro olefin 暨南大学 2023-04-11 CN disclosed