SCHEMBL28985017

SCHEMBL28985017

COC(c1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 10/20 0.45
AKR1C3 P42330 2/20 0.40
AKR1C2 P52895 2/20 0.40
FFAR1 O14842 3/20 0.40
CASR P41180 2/20 0.39
PDE2A O00408 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12199230 0.94 PDE2A (0.42) KIF11AKR1C3AKR1C2CASRPDE2A
SCHEMBL28961295 0.86 KIF11 (0.42) KIF11AKR1C3AKR1C2FFAR1CASR
SCHEMBL28985000 0.83 KIF11 (0.42) KIF11
SCHEMBL28985020 0.79 KIF11 (0.44) KIF11AKR1C2PDE2A
SCHEMBL28985275 0.79 CTSL (0.38) AKR1C2
SCHEMBL12282257 0.76 AOC3 (0.42)
SCHEMBL12282035 0.76 CHRNA7 (0.37) KIF11AKR1C3AKR1C2
SCHEMBL28985015 0.76 CYP2A6 (0.41)
SCHEMBL28985271 0.75 LIPE (0.31)
SCHEMBL17906217 0.75 CYP3A4 (0.39) KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115948752-A Reaction method for selective fluorination functionalization of harmonious difluoro olefin 暨南大学 2023-04-11 CN disclosed