Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299865 | 0.69 | KDM4E (0.45) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL10301440 | 0.69 | MAPT (0.56) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL4090912 | 0.68 | MAPT (0.44) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL299972 | 0.67 | MAPT (0.42) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL8508163 | 0.66 | MAPT (0.42) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL197157 | 0.66 | SNCA (0.50) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL13183056 | 0.64 | MAPT (0.47) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL10186730 | 0.64 | KDM4E (0.61) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL884175 | 0.64 | — | — | |
| SCHEMBL289680 | 0.64 | KDM4E (0.60) | MAPTKDM4ERXFP1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |