SCHEMBL299972

SCHEMBL299972

Cc1cnc(-c2ccc(Br)s2)s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.42
KDM4E B2RXH2 4/20 0.42
RAB9A P51151 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A1 P00352 3/20 0.42
HSD17B10 Q99714 2/20 0.42
PPARG P37231 2/20 0.42
NCOA2 Q15596 2/20 0.42
RXFP1 Q9HBX9 2/20 0.42
NPC1 O15118 2/20 0.42
TP53 P04637 1/20 0.42
HPGD P15428 1/20 0.42
NCOA1 Q15788 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
NCOA3 Q9Y6Q9 1/20 0.42
NOS1 P29475 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
ALOX12 P18054 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20175446 0.86 NOS1 (0.44) MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1
SCHEMBL10141290 0.84 NOS1 (0.43) MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1
SCHEMBL867864 0.82 MAPT (0.46) MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1
SCHEMBL152406 0.77 MAPT (0.42) MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1
SCHEMBL12462949 0.77 NOS1 (0.38) NOS1SRCCDK2ZAP70SYK
SCHEMBL8270602 0.77 CYP2A6 (0.42) MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1
SCHEMBL20288050 0.76 NOS1 (0.36) NOS1SRCCDK2ZAP70SYK
SCHEMBL4090912 0.74 MAPT (0.44) MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1
SCHEMBL10141023 0.74 NOS1 (0.35) NOS1SRCCDK2ZAP70SYK
SCHEMBL10002194 0.73 NOS1 (0.55) MAPTRAB9ASMN1; SMN2NPC1NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427447-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION Pike Pharma GmbH (CH) 2012-03-14 EP disclosed
WO-2010128163-A2 SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION PIKE PHARMA GMBH (CH) 2010-11-11 WO disclosed