Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | DUT | P33316 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18359857 | 0.83 | HSD11B1 (0.56) | HSD11B1CYP19A1P2RX7SIRT2SIRT1 | |
| SCHEMBL15874678 | 0.81 | HSD11B1 (0.65) | HSD11B1CYP19A1P2RX7DUTSIRT2 | |
| SCHEMBL4195851 | 0.78 | HSD11B1 (0.61) | HSD11B1CYP19A1P2RX7POLBSIRT2 | |
| SCHEMBL17167327 | 0.78 | GGPS1 (0.52) | HSD11B1GGPS1DUTTLR7 | |
| SCHEMBL21606708 | 0.77 | HSD11B1 (0.77) | HSD11B1P2RX7SIRT2SIRT1CYP11B1 | |
| SCHEMBL27855037 | 0.77 | HSD11B1 (0.56) | HSD11B1CYP19A1P2RX7SIRT2SIRT1 | |
| SCHEMBL3546972 | 0.76 | GGPS1 (0.51) | HSD11B1GGPS1DUTTLR7 | |
| SCHEMBL9926336 | 0.76 | GGPS1 (0.51) | GGPS1DUT | |
| SCHEMBL18354111 | 0.76 | HSD11B1 (0.52) | HSD11B1CYP19A1P2RX7DUTSIRT2 | |
| SCHEMBL20841014 | 0.76 | HSD11B1 (0.56) | HSD11B1CYP19A1P2RX7DUTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943004-B1 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | SCRIPPS RESEARCH INST (US) | 2015-06-03 | — | — | EP | disclosed |
| EP-1943004-B1 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | SCRIPPS RESEARCH INST (US) | 2015-06-03 | — | — | EP | disclosed |
| US-8372986-B2 | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| US-8372986-B2 | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| CN-101316640-B | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | SCRIPPS RESEARCH INST | 2013-02-06 | — | — | CN | disclosed |
| US-20100286405-A1 | Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-11-11 | — | — | US | disclosed |
| US-20100286405-A1 | Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-11-11 | — | — | US | disclosed |
| CN-101316640-A | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | SCRIPPS RESEARCH INST (US) | 2008-12-03 | — | — | CN | disclosed |
| EP-1943004-A2 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | The Scripps Research Institute (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007041451-A2 | RUTHENIUM-CATALYZED CYCLOADDITION OF ALKYNES AND ORGANIC AZIDES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286405-A1 | Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides | CBR3, AOC3, CYB5R3 | HSD11B1 1498/4885GGPS1 1859/4885CYP19A1 685/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.