SCHEMBL28986385

SCHEMBL28986385

CCOC(=O)C(=O)CC(Cl)(c1ccccc1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
MAPT P10636 3/20 0.44
ALDH1A1 P00352 2/20 0.44
TSHR P16473 1/20 0.41
PIN1 Q13526 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
GAA P10253 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
CYP2C19 P33261 2/20 0.40
CYP1A2 P05177 2/20 0.40
ATM Q13315 1/20 0.40
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40
CES2 O00748 1/20 0.40
ACHE P22303 1/20 0.40
CES1 P23141 1/20 0.40
HIF1A Q16665 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11839587 0.83 SMN1; SMN2 (0.49) MEN1KMT2AALDH1A1TSHRPIN1
SCHEMBL5203973 0.82 MEN1 (0.47) MEN1KMT2AMAPTALDH1A1TSHR
SCHEMBL4488702 0.79 CYP2C19 (0.50) MEN1KMT2AMAPTALDH1A1TSHR
SCHEMBL28970087 0.77 CYP1A2 (0.48) KMT2AMAPTALDH1A1TSHRCYP2C19
SCHEMBL2421522 0.73 CYP1A2 (0.53) MEN1KMT2AMAPTALDH1A1TSHR
SCHEMBL7527310 0.73 PIN1 (0.53) MEN1KMT2AMAPTALDH1A1TSHR
SCHEMBL705709 0.73 PIN1 (0.53) MEN1KMT2AMAPTALDH1A1TSHR
SCHEMBL3428073 0.71 PIN1 (0.51) MEN1KMT2AALDH1A1TSHRPIN1
SCHEMBL10708966 0.71 MMP8 (0.53) MEN1KMT2AMAPTALDH1A1TSHR
SCHEMBL2422372 0.70 PIN1 (0.54) MEN1KMT2AMAPTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115806530-B Preparation method of bisbenzoxazole acid 新发药业有限公司 2024-08-13 CN disclosed
CN-115806530-A Preparation method of isoxadifen 新发药业有限公司 2023-03-17 CN disclosed
CN-115806530-A Preparation method of isoxadifen 新发药业有限公司 2023-03-17 CN disclosed