Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.54 |
| ▸ | FYN | P06241 | 10/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGR | P09769 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203700 | 0.87 | NTRK1 (0.54) | NTRK1FYNNTRK3NTRK2MKNK1 | |
| SCHEMBL2902453 | 0.86 | PIM1 (0.61) | NTRK1FYNNTRK3NTRK2MKNK1 | |
| SCHEMBL1203685 | 0.85 | NTRK1 (0.54) | NTRK1FYNNTRK3NTRK2MKNK1 | |
| SCHEMBL2905622 | 0.82 | FYN (0.72) | NTRK1FYN | |
| Hydrochloric Acid SCHEMBL1202037 | 0.81 | FYN (0.71) | NTRK1FYN | |
| SCHEMBL1202088 | 0.80 | FYN (0.63) | NTRK1FYNNTRK3NTRK2MKNK1 | |
| SCHEMBL1203062 | 0.79 | FYN (0.60) | NTRK1FYNNTRK3NTRK2PIM1 | |
| SCHEMBL2905868 | 0.79 | FYN (0.50) | NTRK1FYNNTRK3NTRK2MKNK1 | |
| SCHEMBL2902438 | 0.79 | FYN (0.57) | NTRK1FYN | |
| SCHEMBL3037765 | 0.79 | MKNK1 (0.77) | NTRK1FYNNTRK3NTRK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |