Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 14/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | TPH1 | P17752 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203600 | 0.86 | FYN (0.59) | FYNNTRK1 | |
| SCHEMBL1202873 | 0.85 | FYN (0.51) | FYNNTRK1 | |
| SCHEMBL1202287 | 0.82 | NTRK1 (0.71) | FYNNTRK1 | |
| SCHEMBL2905622 | 0.81 | FYN (0.72) | FYNNTRK1 | |
| SCHEMBL2905868 | 0.81 | FYN (0.50) | FYNNTRK1 | |
| SCHEMBL2902453 | 0.81 | PIM1 (0.61) | FYNNTRK1 | |
| Hydrochloric Acid SCHEMBL1202037 | 0.81 | FYN (0.71) | FYNNTRK1 | |
| SCHEMBL1202088 | 0.80 | FYN (0.63) | FYNNTRK1 | |
| SCHEMBL2898694 | 0.79 | NTRK1 (0.54) | FYNNTRK1 | |
| SCHEMBL1203062 | 0.79 | FYN (0.60) | FYNNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |