Alpha-Ketoglutaric Acid

Alpha-Ketoglutaric Acid

SCHEMBL28986949

CC(=O)C(=O)Oc1ccc(O)cc1.O=C(O)CCC(=O)C(=O)O

nearest known ligand 0.42

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.42
SLC13A3 Q8WWT9 1/20 0.42
EGLN1 Q9GZT9 1/20 0.42
OR51E2 Q9H255 1/20 0.42
ALDH1A1 P00352 3/20 0.40
MAPT P10636 3/20 0.40
KDM4E B2RXH2 2/20 0.40
CYP1A1 P04798 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ELANE P08246 3/20 0.38
ESR1 P03372 2/20 0.37
CYP3A4 P08684 1/20 0.37
ESR2 Q92731 1/20 0.37
POLB P06746 1/20 0.37
PCNA P12004 1/20 0.37
HTT P42858 2/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CYP19A1 P11511 1/20 0.35
KMT2A Q03164 2/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Hydroxyphenylpyruvic Acid SCHEMBL20797984 0.82 FNTA (0.49) ALDH1A1ELANECYP3A4POLBHTT
SCHEMBL24158 0.82 ELANE (0.48) ALDH1A1MAPTKDM4EELANEESR1
Water SCHEMBL28201047 0.78 ELANE (0.46) ALDH1A1MAPTKDM4EELANEESR1
SCHEMBL22511128 0.74 FFAR1 (0.57) L3MBTL1KMT2ALMNA
SCHEMBL28770121 0.73 KMT2A (0.57) ALDH1A1MAPTKDM4ECYP1A1ELANE
SCHEMBL1463536 0.72 MEN1 (0.46) MAPTKDM4EELANEESR1ESR2
4-Hydroxyphenylpyruvic Acid SCHEMBL6248455 0.70 CA2 (0.59) MAPK1SLC13A3EGLN1OR51E2ALDH1A1
Methacrylic Acid SCHEMBL8512987 0.70 ELANE (0.60) MAPTKDM4EELANEESR1ESR2
Alpha-Ketoglutaric Acid SCHEMBL14940763 0.70 CA2 (0.70) MAPK1SLC13A3EGLN1OR51E2ALDH1A1
Acetaldehyde SCHEMBL729633 0.70 KMT2A (0.53) ALDH1A1MAPTKDM4ECYP1A1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115960811-A Bacterial strain for synthesizing salidroside through efficient biotransformation and application thereof 上海锐康生物技术研发有限公司 2023-04-14 CN disclosed