Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.32 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.32 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL9784975 | 0.86 | ALDH1A1 (0.42) | TSHRALDH1A1LMNASLC6A6CYP2C19 | |
| 1,4-Butanediol SCHEMBL28294560 | 0.82 | GRIA1 (0.40) | TSHRALDH1A1LMNATP53GRIA1 | |
| 1,4-Butanediol SCHEMBL7623431 | 0.82 | GRIA1 (0.40) | TSHRALDH1A1LMNATP53GRIA1 | |
| Monoethanolamine SCHEMBL1833264 | 0.79 | — | — | |
| Monoethanolamine SCHEMBL4709287 | 0.79 | TSHR (0.53) | TSHRALDH1A1LMNASLC6A6CYP2C19 | |
| Methylamine SCHEMBL5559367 | 0.78 | — | — | |
| Sulfuric Acid SCHEMBL1837317 | 0.78 | TSHR (0.61) | TSHRALDH1A1LMNASLC6A6CYP2C19 | |
| Sulfuric Acid SCHEMBL700465 | 0.78 | — | — | |
| SCHEMBL5354 | 0.78 | — | — | |
| Monoethanolamine SCHEMBL11144600 | 0.77 | TSHR (0.50) | TSHRALDH1A1LMNASLC6A6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115989239-A | Human interferon beta variants with double mutations and methods for improving the stability of human interferon beta variants | 瑷备恩有限公司 | 2023-04-18 | — | — | CN | claimed |