SCHEMBL28990167

SCHEMBL28990167

CCOC(=O)c1ccnc(C)c1.Cc1cc(C(=O)O)ccn1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.54
CYP2C19 P33261 1/20 0.54
JMJD6 Q6NYC1 4/20 0.53
KDM4E B2RXH2 3/20 0.53
KDM5C P41229 3/20 0.53
KDM4C Q9H3R0 3/20 0.53
KDM6B O15054 2/20 0.53
KDM2A Q9Y2K7 2/20 0.53
KDM3A Q9Y4C1 2/20 0.53
PIK3CA P42336 1/20 0.51
CA12 O43570 3/20 0.49
CA1 P00915 3/20 0.49
CA2 P00918 3/20 0.49
CA7 P43166 3/20 0.49
CA9 Q16790 3/20 0.49
CA14 Q9ULX7 3/20 0.49
KDM5A P29375 2/20 0.46
KDM5B Q9UGL1 2/20 0.46
TET3 O43151 1/20 0.46
KDM4A O75164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL363249 0.94 JMJD6 (0.58) CYP2C9CYP2C19JMJD6KDM4EKDM5C
SCHEMBL28271627 0.88 KDM5C (0.69) CYP2C9CYP2C19JMJD6KDM4EKDM5C
SCHEMBL29527921 0.85 KDM4C (0.61) JMJD6KDM4EKDM5CKDM4CKDM6B
SCHEMBL353289 0.85 KDM4C (0.61) JMJD6KDM4EKDM5CKDM4CKDM6B
Hydrochloric Acid SCHEMBL11077926 0.83 KDM4C (0.59) JMJD6KDM4EKDM5CKDM4CKDM6B
Hydrochloric Acid SCHEMBL1256781 0.83 KDM4C (0.59) JMJD6KDM4EKDM5CKDM4CKDM6B
SCHEMBL16578099 0.83 KDM4E (0.61) CYP2C9CYP2C19JMJD6KDM4EKDM5C
SCHEMBL1920448 0.83 FTO (0.61) CYP2C9CYP2C19JMJD6KDM4EKDM5C
SCHEMBL30171421 0.80 JMJD6 (0.76) JMJD6KDM4EKDM5CKDM4CKDM6B
SCHEMBL811785 0.80 JMJD6 (0.76) JMJD6KDM4EKDM5CKDM4CKDM6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116034107-A Quinuclidinone analogs as anticancer agents 新波制药有限公司 2023-04-28 CN disclosed