Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 3/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2902440 | 0.92 | ATM (0.38) | KDM4EATMFFAR1ITGB1ITGA4 | |
| SCHEMBL27848799 | 0.90 | L3MBTL1 (0.37) | KDM4EATMITGB1ITGA4ALDH1A1 | |
| SCHEMBL27830432 | 0.86 | GPR174 (0.38) | KDM4EALDH1A1SMN1; SMN2SLC6A2SLC6A3 | |
| SCHEMBL27830414 | 0.82 | PSEN1 (0.41) | ATMALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL478069 | 0.81 | PSEN1 (0.43) | KDM4EATMFFAR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2903614 | 0.79 | CHRM3 (0.38) | ATMCHRM3 | |
| SCHEMBL2903673 | 0.77 | PSEN1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27830418 | 0.76 | PSEN1 (0.42) | KDM4EALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL2903596 | 0.75 | KDM4E (0.38) | KDM4EATMALDH1A1SMN1; SMN2SLC6A2 | |
| SCHEMBL478265 | 0.75 | PSEN1 (0.54) | ATMFFAR1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903347-B | Piperidinyl and piperazinyl modulators of gamma-secretase | JANSSEN PHARMACEUTICA NV | 2013-03-27 | — | — | CN | disclosed |
| EP-2212287-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052126-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |