Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904747 | 0.91 | PSEN1 (0.39) | CACNA1BMEN1KMT2APSEN1PSEN2 | |
| SCHEMBL2902243 | 0.85 | ALDH1A1 (0.42) | KDM4EALDH1A1SMN1; SMN2ATML3MBTL1 | |
| SCHEMBL2916426 | 0.85 | UBE2M (0.39) | KDM4EALDH1A1 | |
| SCHEMBL2919438 | 0.82 | CTSK (0.41) | — | |
| SCHEMBL27848908 | 0.82 | ATM (0.40) | KDM4EALDH1A1SMN1; SMN2DPP4DPP7 | |
| SCHEMBL27848934 | 0.82 | OPRM1 (0.38) | KDM4EALDH1A1L3MBTL1LMNANPSR1 | |
| SCHEMBL27830429 | 0.81 | KDM4E (0.36) | KDM4EALDH1A1SMN1; SMN2DPP4DPP7 | |
| SCHEMBL27830420 | 0.80 | L3MBTL1 (0.34) | ALDH1A1SMN1; SMN2RENATML3MBTL1 | |
| SCHEMBL27830432 | 0.80 | GPR174 (0.38) | KDM4EALDH1A1SMN1; SMN2DPP4DPP7 | |
| SCHEMBL27894666 | 0.80 | SLC6A3 (0.42) | ALDH1A1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903347-A | Piperidinyl and piperazinyl modulators of gamma-secretase | JANSSEN PHARMACEUTICA NV | 2010-12-01 | — | — | CN | disclosed |
| EP-2212287-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052126-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |