Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 15/20 | 0.38 |
| ▸ | CIT | O14578 | 3/20 | 0.38 |
| ▸ | GAK | O14976 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 2/20 | 0.37 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28992906 | 0.77 | AAK1 (0.46) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL1690559 | 0.74 | NOTUM (0.44) | AAK1CYP3A4QDPRSMARCA2 | |
| SCHEMBL19880348 | 0.74 | APP (0.55) | CYP3A4QDPRAPP | |
| SCHEMBL24897799 | 0.72 | AAK1 (0.51) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL30559520 | 0.72 | PLAU (0.43) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL4135163 | 0.69 | SMARCA2 (0.44) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL29769088 | 0.69 | SMARCA2 (0.44) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL28992891 | 0.69 | DYRK1A (0.60) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL12302767 | 0.68 | WNT3A (0.56) | WNT3A | |
| SCHEMBL13590994 | 0.67 | ALOX5 (0.62) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023051749-A1 | AAK1 INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2023-04-06 | — | — | WO | disclosed |
| CN-115872927-A | AAK1 inhibitors and uses thereof | 武汉人福创新药物研发中心有限公司 | 2023-03-31 | — | — | CN | disclosed |