Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRE | P78334 | 1/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4919214 | 0.82 | NR4A2 (0.50) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL4919209 | 0.78 | KDM4E (0.52) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL5473200 | 0.76 | PBRM1 (0.46) | MEN1KMT2AMAPTALDH1A1NR4A2 | |
| SCHEMBL1642680 | 0.74 | KDM4E (0.42) | MEN1KMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL1642667 | 0.73 | ALDH1A1 (0.46) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL9587428 | 0.72 | YTHDC1 (0.49) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL16756178 | 0.72 | CYP3A4 (0.51) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6684094 | 0.70 | NR4A2 (0.69) | MEN1KMT2AMAPTALDH1A1USP2 | |
| SCHEMBL29135561 | 0.69 | GAA (0.45) | MEN1KMT2AMAPTALDH1A1ATM | |
| SCHEMBL27392340 | 0.69 | ALDH1A1 (0.47) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114276411-B | Solid phase synthesis method of cyclic peptide compound containing trithioether bond | 北京大学深圳研究生院 | 2024-02-09 | — | — | CN | claimed |
| US-8865655-B2 | Depsipeptides and their therapeutic use | KARUS THERAPEUTICS LIMITED (GB) | 2014-10-21 | — | — | US | claimed |
| EP-2089416-B1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | UNIV SOUTHAMPTON (GB) | 2014-02-26 | — | — | EP | claimed |
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | claimed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | claimed |
| US-20100056434-A1 | Depsipeptides and Their Therapeutic Use | UNIVERSITY OF SOUTHAMPTON (GB) | 2010-03-04 | — | — | US | claimed |
| US-20100056435-A1 | Depsipeptides and Their Therapeutic Use | KARUS THERAPEUTICS LIMITED (GB) | 2010-03-04 | — | — | US | claimed |
| EP-2089415-A1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | Karus Therapeutics Limited (GB) | 2009-08-19 | — | — | EP | claimed |
| EP-2089416-A1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | UNIVERSITY OF SOUTHAMPTON (GB) | 2009-08-19 | — | — | EP | claimed |
| WO-2008062201-A1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | KARUS THERAPEUTICS LIMITED (GB) | 2008-05-29 | — | — | WO | claimed |
| WO-2008062232-A1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | UNIVERSITY OF SOUTHAMPTON (GB) | 2008-05-29 | — | — | WO | claimed |
| CN-114276411-B | Solid phase synthesis method of cyclic peptide compound containing trithioether bond | 北京大学深圳研究生院 | 2024-02-09 | — | — | CN | disclosed |
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |
| EP-1527074-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004013144-A1 | BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056435-A1 | Depsipeptides and Their Therapeutic Use | HDAC3, HDAC6, HDAC7 | GABRA1 1486/4885GABRG2 2262/4885GABRB3 1287/4885 |
| US-20100056434-A1 | Depsipeptides and Their Therapeutic Use | HDAC11, HDAC1, HDAC6 | GABRA1 3171/4885GABRG2 3582/4885GABRB3 2755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.