Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24532111 | 0.78 | MEN1 (0.61) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL29680909 | 0.78 | MEN1 (0.61) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL29681544 | 0.72 | KMT2A (0.63) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL18394788 | 0.72 | KMO (0.51) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL30689227 | 0.72 | PRKDC (0.56) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL18394573 | 0.72 | PRKDC (0.56) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL29681119 | 0.71 | MEN1 (0.55) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL24532295 | 0.71 | MEN1 (0.55) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL2899403 | 0.71 | MAPT (0.48) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL29125442 | 0.70 | KMT2A (0.57) | MEN1KMT2AKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166852-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | Helicon Therapeutics, Inc. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154438-A1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS, INC. (US) | 2008-12-18 | — | — | WO | disclosed |