SCHEMBL28995384

SCHEMBL28995384

CCCSc1c(Cl)cccc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.40
HSD11B1 P28845 1/20 0.38
APLNR P35414 2/20 0.37
KDM4E B2RXH2 1/20 0.36
P2RX7 Q99572 1/20 0.36
PIEZO1 Q92508 1/20 0.34
CTSS P25774 2/20 0.33
CTSK P43235 2/20 0.33
PTGS2 P35354 1/20 0.33
PYCR1 P32322 1/20 0.33
NR1H2 P55055 2/20 0.32
NR1H3 Q13133 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
S1PR1 P21453 1/20 0.32
TYK2 P29597 1/20 0.32
NOS3 P29474 1/20 0.32
NOS1 P29475 1/20 0.32
NOS2 P35228 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28975161 0.86 P2RX7 (0.38) HSD11B1P2RX7PIEZO1CTSSCTSK
SCHEMBL33745024 0.86 P2RX7 (0.38) HSD11B1P2RX7PIEZO1CTSSCTSK
SCHEMBL6681359 0.81 AR (0.41) ARHSD11B1APLNRKDM4ECTSS
SCHEMBL6680112 0.80 APLNR (0.42) ARAPLNRKDM4ENOS3NOS1
SCHEMBL28995308 0.80 AR (0.40) ARHSD11B1APLNRKDM4EP2RX7
SCHEMBL23318473 0.79 AR (0.39) ARAPLNRKDM4ENOS3NOS1
SCHEMBL6679512 0.78 ATM (0.39) ARAPLNRKDM4EPTGS2L3MBTL1
SCHEMBL21192823 0.77 P2RX7 (0.41) ARHSD11B1P2RX7PTGS2PYCR1
SCHEMBL28918930 0.76 P2RX7 (0.39) ARHSD11B1KDM4EP2RX7PTGS2
SCHEMBL31563751 0.74 AR (0.38) ARAPLNRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115703726-B Trifluoromethyl phenyl sulfide compound 上海泰初化工技术有限公司 2024-04-02 CN disclosed
CN-115703726-A Trifluoromethyl phenyl sulfide compound 上海泰初化工技术有限公司 2023-02-17 CN disclosed