SCHEMBL28918930

SCHEMBL28918930

FC(F)(F)c1cccc(Cl)c1Sc1c(Cl)cccc1C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.39
HSD11B1 P28845 1/20 0.38
TYK2 P29597 1/20 0.37
LDHA P00338 2/20 0.37
LDHB P07195 2/20 0.37
PTGS2 P35354 1/20 0.35
KDM4E B2RXH2 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HSD17B10 Q99714 1/20 0.34
NOTUM Q6P988 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
SLC22A12 Q96S37 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2A6 P11509 1/20 0.33
MAPK14 Q16539 1/20 0.33
AR P10275 1/20 0.33
ALDH1A1 P00352 2/20 0.33
MEN1 O00255 1/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21192823 0.83 P2RX7 (0.41) P2RX7HSD11B1TYK2LDHALDHB
SCHEMBL10976334 0.83 P2RX7 (0.37) P2RX7HSD11B1TYK2LDHALDHB
SCHEMBL33745024 0.79 P2RX7 (0.38) P2RX7HSD11B1TYK2PTGS2L3MBTL1
SCHEMBL29115452 0.79 SLC22A12 (0.39) P2RX7HSD11B1TYK2LDHALDHB
SCHEMBL28975161 0.79 P2RX7 (0.38) P2RX7HSD11B1TYK2PTGS2L3MBTL1
SCHEMBL28918923 0.76 HSD11B1 (0.37) P2RX7HSD11B1PTGS2KDM4ESMN1; SMN2
SCHEMBL28715207 0.75 CYP1A2 (0.47) CYP1A2CYP2A6ALDH1A1MEN1KMT2A
SCHEMBL29764291 0.75 P2RX7 (0.52) P2RX7HSD11B1TYK2PTGS2KDM4E
SCHEMBL312929 0.75 P2RX7 (0.52) P2RX7HSD11B1TYK2PTGS2KDM4E
SCHEMBL28918938 0.74 HSD11B1 (0.38) P2RX7HSD11B1SMN1; SMN2L3MBTL1AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115490622-A Trifluoromethyl thiophenol compound 上海泰初化工技术有限公司 2022-12-20 CN disclosed