SCHEMBL28997293

SCHEMBL28997293

N#CCC1CCC(=O)N1c1cccc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.42
MAPT P10636 2/20 0.42
ALDH1A1 P00352 2/20 0.42
MGLL Q99685 1/20 0.40
KMT2A Q03164 2/20 0.39
GAA P10253 1/20 0.39
AR P10275 1/20 0.39
ALOX15 P16050 1/20 0.39
TSHR P16473 1/20 0.39
P2RX7 Q99572 1/20 0.38
TP53 P04637 1/20 0.38
MDM2 Q00987 1/20 0.38
NOTUM Q6P988 1/20 0.38
DRD2 P14416 4/20 0.38
DRD3 P35462 3/20 0.38
KCNH2 Q12809 2/20 0.38
HTR1A P08908 1/20 0.38
CYP2D6 P10635 1/20 0.38
HTR1D P28221 1/20 0.38
HTR2A P28223 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30226142 1.00 KDM4E (0.42) KDM4EMAPTALDH1A1MGLLKMT2A
SCHEMBL28997149 0.85 FAAH (0.41) MAPTALDH1A1MGLLKMT2AGAA
SCHEMBL30226199 0.85 MGLL (0.41) ALDH1A1MGLLKMT2AARMEN1
SCHEMBL28997153 0.85 MGLL (0.41) ALDH1A1MGLLKMT2AARMEN1
SCHEMBL30226089 0.85 FAAH (0.41) MAPTALDH1A1MGLLKMT2AGAA
SCHEMBL28997274 0.85 AR (0.38) KDM4EMAPTALDH1A1MGLLKMT2A
SCHEMBL28997140 0.84 PTGER2 (0.39) KDM4EMAPTALDH1A1P2RX7NOTUM
SCHEMBL30226008 0.81 AR (0.44) KDM4EMAPTALDH1A1KMT2AGAA
SCHEMBL28997299 0.81 AR (0.44) KDM4EMAPTALDH1A1KMT2AGAA
SCHEMBL31440006 0.79 NOTUM (0.45) KMT2AARTSHRP2RX7TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115894323-A Method for self-cyclizing cyanation of enaminoaniline compound 湖北工业大学 2023-04-04 CN disclosed