Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.65 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.65 |
| ▸ | DHODH | Q02127 | 2/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28295520 | 0.95 | CDC7 (0.64) | CDC7DBF4DHODHTRPM8LMNA | |
| SCHEMBL289229 | 0.89 | CDC7 (0.73) | CDC7DBF4TRPM8LMNAKDM4E | |
| SCHEMBL290104 | 0.87 | KDM4E (0.59) | CDC7DBF4DHODHTRPM8LMNA | |
| SCHEMBL1316281 | 0.86 | CDC7 (0.77) | CDC7DBF4TRPM8LMNAKDM4E | |
| SCHEMBL28295517 | 0.84 | CDC7 (0.51) | CDC7DBF4DHODHTRPM8LMNA | |
| SCHEMBL2880861 | 0.84 | CDC7 (0.67) | CDC7DBF4TRPM8LMNAKDM4E | |
| SCHEMBL289852 | 0.83 | SMN1; SMN2 (0.73) | LMNAKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2085303 | 0.83 | CDC7 (0.73) | CDC7DBF4TRPM8LMNAKDM4E | |
| SCHEMBL892889 | 0.83 | CDC7 (0.77) | CDC7DBF4TRPM8LMNAKDM4E | |
| SCHEMBL14109005 | 0.83 | DHODH (0.60) | CDC7DBF4DHODHTRPM8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |