Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 7/20 | 0.77 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.77 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | RARA | P10276 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 1/20 | 0.59 |
| ▸ | RARG | P13631 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289229 | 0.97 | CDC7 (0.73) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL290013 | 0.93 | CDC7 (0.68) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL8867673 | 0.90 | CDC7 (0.67) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL2880861 | 0.90 | CDC7 (0.67) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL892889 | 0.88 | CDC7 (0.77) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL290681 | 0.88 | CDC7 (0.61) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL289156 | 0.88 | ALDH1A1 (0.65) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL8867028 | 0.87 | CDC7 (0.71) | CDC7DBF4TRPM8SMN1; SMN2LMNA | |
| SCHEMBL4503056 | 0.87 | CDC7 (0.88) | CDC7DBF4TRPM8ALDH1A1KDM4E | |
| SCHEMBL6338322 | 0.87 | TRPM8 (1.00) | CDC7DBF4TRPM8KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2024-05-23 | — | — | US | disclosed |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2024-02-13 | — | — | US | disclosed |
| CN-113461634-B | Thiazole hydrazide compound and preparation method and application thereof | 贵州大学 | 2023-07-04 | — | — | CN | disclosed |
| CN-111333636-B | Thiazole amide derivatives and application thereof in antitumor drugs | 福建太平洋制药有限公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-113461634-A | Thiazole hydrazide compounds and preparation method and application thereof | 贵州大学 | 2021-10-01 | — | — | CN | disclosed |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | THE UNIVERSITY OF TOLEDO (US) | 2021-06-03 | — | — | US | disclosed |
| CN-107162913-B | Novel deuterated phenylpropionic acid derivative, preparation method thereof and application thereof as medicine | 中国药科大学 | 2021-04-30 | — | — | CN | disclosed |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2021-03-09 | — | — | US | disclosed |
| US-10776461-B2 | Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same | THE UNIVERSITY OF TOLEDO (US) | 2020-09-15 | — | — | US | disclosed |
| EP-3124489-B1 | THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN INC (US) | 2020-07-15 | — | — | EP | disclosed |
| EP-2016078-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | FIBROGEN, INC. | 2008-01-03 | — | — | US | disclosed |
| WO-2007115315-A2 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS AS HIF MODULATORS | FIBROGEN, INC. (US) | 2007-10-11 | — | — | WO | disclosed |
| CN-1678596-A | Novel 2-arylthiazole compounds as PPAR alpha and PPAR gamma agonists | HOFFMANN LA ROCHE (CH) | 2005-10-05 | — | — | CN | disclosed |
| EP-1537091-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| US-6809110-B2 | NONINSULIN DEPENDENT DIABETES; SUCH AS 2-ETHOXY-3-(4-(2-(5-METHYL-2-PHENYL-THIAZOL-4-YL)-ETHOXY)-BENZO(B)THIOPHEN-7-YL)-PROPIONIC ACID | HOFFMANN-LA ROCHE INC. | 2004-10-26 | — | — | US | disclosed |
| US-20040110807-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-10 | — | — | US | disclosed |
| US-6710063-B1 | Activators of PPAR delta | SMITHKLINE BEECHAM CORPORATION | 2004-03-23 | — | — | US | disclosed |
| WO-2004020420-A1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-03-11 | — | — | WO | disclosed |
| US-6518290-B1 | Compounds that activate or otherwise interact with one or more of the PPARs have been implicated in the regulation of triglyceride and cholesterol levels in animal models | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10776461-B2 | Analogs of proxisome proliferator activated receptor (PPAR) agonists and methods of using the same | PPARG, PPARA, PPARD | CDC7 3033/4885DBF4 4368/4885TRPM8 4522/4885 |
| US-20240166613-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | CDC7 3409/4885DBF4 4588/4885TRPM8 4325/4885 |
| US-10941125-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | CDC7 3385/4885DBF4 4594/4885TRPM8 4350/4885 |
| US-11897852-B2 | Proxisome proliferator activated receptor (PPAR) compounds and methods of using the same | PPARG, PPARA, PPARD | CDC7 3385/4885DBF4 4594/4885TRPM8 4350/4885 |
| US-20080004309-A1 | PYRROLO- AND THIAZOLO-PYRIDINE COMPOUNDS, AND METHODS OF USE THEREOF | HIF1AN, HIF1A, EGLN2 | CDC7 2482/4885DBF4 2072/4885TRPM8 3499/4885 |
| US-20040110807-A1 | Thiazole derivatives | SLC5A1, GPR119, INSR | CDC7 4504/4885DBF4 3718/4885TRPM8 2781/4885 |
| US-20210163431-A1 | PROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR) COMPOUNDS AND METHODS OF USING THE SAME | PPARG, PPARA, PPARD | CDC7 3385/4885DBF4 4594/4885TRPM8 4350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.