Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350754 | 1.00 | FGFR1 (0.62) | FGFR1ALDH1A1HTTMKNK1MKNK2 | |
| SCHEMBL19459554 | 0.82 | ALDH1A1 (0.60) | FGFR1ALDH1A1HTTMKNK1MKNK2 | |
| SCHEMBL3834819 | 0.80 | FGFR1 (0.72) | FGFR1ALDH1A1HTTMAPT | |
| SCHEMBL29449347 | 0.77 | FGFR1 (1.00) | FGFR1ALDH1A1HTTMAPTMITF | |
| SCHEMBL2308773 | 0.77 | FGFR1 (1.00) | FGFR1ALDH1A1HTTMAPTMITF | |
| SCHEMBL2899962 | 0.76 | HTT (0.55) | FGFR1HTTMKNK1MKNK2 | |
| SCHEMBL19350753 | 0.76 | MKNK1 (0.59) | FGFR1ALDH1A1HTTMKNK1MKNK2 | |
| SCHEMBL3300702 | 0.75 | FGFR1 (0.70) | FGFR1ALDH1A1HTTMKNK1MKNK2 | |
| SCHEMBL3296982 | 0.75 | ALDH1A1 (0.70) | FGFR1ALDH1A1HTTMKNK1MKNK2 | |
| SCHEMBL2465676 | 0.75 | MKNK2 (0.67) | FGFR1ALDH1A1HTTMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |