Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289445 | 0.80 | CYP19A1 (0.48) | KDM4EALDH1A1HPGDCA2MEN1 | |
| SCHEMBL290387 | 0.76 | KDM4E (0.47) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8316143 | 0.75 | BACE1 (0.46) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL289947 | 0.72 | ALDH1A1 (0.53) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL890218 | 0.69 | NPC1 (0.50) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2096148 | 0.68 | MAPT (0.61) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL144533 | 0.67 | BACE1 (0.65) | MAPTKDM4EALDH1A1BACE1PDE3B | |
| SCHEMBL9151832 | 0.67 | BACE1 (0.56) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL289627 | 0.67 | KDM4E (0.50) | NPC1MAPTRAB9ASMN1; SMN2KDM4E | |
| SCHEMBL8314504 | 0.67 | RAB9A (0.70) | NPC1MAPTRAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |