Leucine

Leucine

SCHEMBL2900058

CC(C)C[C@H](N)C(=O)O.NO

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 1/20 0.95
▸ SLC1A2 P43004 7/20 0.71
▸ SLC1A3 P43003 6/20 0.71
▸ SLC1A1 P43005 7/20 0.60
▸ GRIK1 P39086 9/20 0.50
▸ GRIK2 Q13002 6/20 0.50
▸ RNPEP Q9H4A4 1/20 0.48
▸ GRIA2 P42262 2/20 0.47
▸ GRIA4 P48058 2/20 0.47
▸ GRIK3 Q13003 2/20 0.47
▸ GRIK5 Q16478 2/20 0.47
▸ GRIA1 P42261 1/20 0.47
▸ PTGS1 P23219 1/20 0.46
▸ SLC7A11 Q9UPY5 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL2900056 1.00 SLC7A5 (0.95) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL331557 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL20362356 0.97 — —
D-Leucine SCHEMBL42012 0.97 — —
D-Leucine SCHEMBL9100148 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL25241602 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL8568063 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL2478164 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL175940 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL8568060 0.97 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7718802-B2 Agonist or antgonist and binders and inversion of agonist; use in the treatment of metabolic, immune, infection-related and melanocortin receptor mediated disorders PALATIN TECHNOLOGIES, INC. (US) 2010-05-18 — — US disclosed
US-20050176728-A1 Agonist or antgonist and binders and inversion of agonist; use in the treatment of metabolic, immune, infection-related and melanocortin receptor mediated disorders PALATIN TECHNOLOGIES, INC. (US) 2005-08-11 — — US disclosed
WO-1991008221-A1 PEPTIDE INHIBITORS OF HIV PROTEASE WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1991-06-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050176728-A1 Agonist or antgonist and binders and inversion of agonist; use in the treatment of metabolic, immune, infection-related and melanocortin receptor mediated disorders MC3R, MC4R, MC1R SLC7A5 704/4885SLC1A2 614/4885SLC1A3 919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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