Leucine

Leucine

SCHEMBL175940

CC(C)CC(N)C(=O)O.CC(C)CC(N)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 1.00
SLC1A2 P43004 7/20 0.74
SLC1A3 P43003 6/20 0.74
SLC1A1 P43005 7/20 0.62
GRIK1 P39086 9/20 0.52
GRIK2 Q13002 6/20 0.52
RNPEP Q9H4A4 1/20 0.50
GRIA2 P42262 2/20 0.48
GRIA4 P48058 2/20 0.48
GRIK3 Q13003 2/20 0.48
GRIK5 Q16478 2/20 0.48
GRIA1 P42261 1/20 0.48
PTGS1 P23219 1/20 0.48
SLC7A11 Q9UPY5 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL8568063 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
D-Leucine SCHEMBL9449950 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL20362356 1.00
Leucine SCHEMBL3888 1.00
D-Leucine SCHEMBL42012 1.00
Leucine SCHEMBL25241602 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL8568060 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL331557 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL2478164 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
D-Leucine SCHEMBL9100148 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10471034-B2 Amino acid compositions and methods for the treatment of liver diseases AXCELLA HEALTH INC. (US) 2019-11-12 US claimed
CN-109402074-A Monooxygenase mutant and its application 凯莱英医药集团(天津)股份有限公司 2019-03-01 CN claimed
CN-105510254-B A kind of method for controlling the leucine for using extraction method to produce to manufacture Amino Acid Compound Injection crystal for raw material 宜昌三峡制药有限公司 2017-12-15 CN claimed
CN-101781325-A Gallium salicylaldehyde amino acid Schiff base quaternary coordination compound, preparation method and application thereof UNIV BEIJING NORMAL 2010-07-21 CN claimed
US-7585333-B2 Fluorescent whitening agent, for whitening synthetic or natural organic materials, especially paper and for the fluorescent whitening and improvement of sun protection factors of textile materials CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-09-08 US claimed
US-20080307585-A1 Fluorescent whitening agent, for whitening synthetic or natural organic materials, especially paper and for the fluorescent whitening and improvement of sun protection factors of textile materials CIBA SPECIALTY CHEMICALS CORP. 2008-12-18 US claimed
CN-1325063-C L-amino acid water-soluble pearl powder and its preparing method SONG TINGSHENG (CN) 2007-07-11 CN claimed
CN-1709282-A L-amino acid water-soluble pearl powder and its preparing method SONG TINGSHENG (CN) 2005-12-21 CN claimed
US-20050203221-A1 Whitening pigments CIBA SPECIALTY CHEMICALS CORP. 2005-09-15 US claimed
CN-1353699-A Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents REDDY RESEARCH FOUNDATION (IN) 2002-06-12 CN claimed
US-12582623-B2 Composition comprising EPA, MA and leucine for improving muscle function N.V. NUTRICIA (NL) 2026-03-24 US disclosed
EP-3487916-B1 FUNCTIONALIZED PARTICULATE BICARBONATE AS BLOWING AGENT, FOAMABLE POLYMER COMPOSITION CONTAINING IT, AND ITS USE IN MANUFACTURING A THERMOPLASTIC FOAMED POLYMER SOLVAY (BE) 2025-09-03 EP disclosed
US-20250241330-A1 PROCESS FOR TREATING PROTEIN-CONTAINING COMPOSITIONS NESTLE SA (CH) 2025-07-31 US disclosed
EP-4574161-A1 PROTEIN SUBSTITUTION COMPOSITION RenaCare NEPHROMED GmbH (DE) 2025-06-25 EP disclosed
CN-119654071-A Bacterial compositions and methods for promoting plant growth 塔斯马尼亚大学 2025-03-18 CN disclosed
CN-1179097-A Carrier particles for dry powder inhalers CO ORDINATED DRUG DEV (GB) 1998-04-15 CN disclosed
EP-0504168-A4 SYNTHETIC CALCITONIN PEPTIDES 1993-09-22 EP disclosed
EP-0504168-A1 SYNTHETIC CALCITONIN PEPTIDES VICAL, INC. (US) 1992-09-23 EP disclosed
WO-1991007978-A1 SYNTHETIC CALCITONIN PEPTIDES VICAL, INC. (US) 1991-06-13 WO disclosed
US-4871716-A CROSSLINKED PROTEIN OR POLYPEPTIDE UNIVERSITY OF FLORIDA (US) 1989-10-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12582623-B2 Composition comprising EPA, MA and leucine for improving muscle function ELOVL1, ELOVL3, ELOVL5 SLC7A5 1386/4885SLC1A2 2605/4885SLC1A3 2008/4885
US-20050203221-A1 Whitening pigments YTHDC1, TRPC1, AOC1 SLC7A5 894/4885SLC1A2 3382/4885SLC1A3 3010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.