Leucine

Leucine

SCHEMBL331557

CC(C)CC(N)C(=O)O.CC(C)C[C@H](N)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 1.00
SLC1A2 P43004 7/20 0.74
SLC1A3 P43003 6/20 0.74
SLC1A1 P43005 7/20 0.62
GRIK1 P39086 9/20 0.52
GRIK2 Q13002 6/20 0.52
RNPEP Q9H4A4 1/20 0.50
GRIA2 P42262 2/20 0.48
GRIA4 P48058 2/20 0.48
GRIK3 Q13003 2/20 0.48
GRIK5 Q16478 2/20 0.48
GRIA1 P42261 1/20 0.48
PTGS1 P23219 1/20 0.48
SLC7A11 Q9UPY5 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL175940 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL8568063 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
D-Leucine SCHEMBL9449950 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL20362356 1.00
Leucine SCHEMBL3888 1.00
D-Leucine SCHEMBL42012 1.00
Leucine SCHEMBL25241602 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL8568060 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
Leucine SCHEMBL2478164 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1
D-Leucine SCHEMBL9100148 1.00 SLC7A5 (1.00) SLC7A5SLC1A2SLC1A3SLC1A1GRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1520073-B1 TRIAZINNYLAMINOSTILBENE DISULPHONIC ACID MIXTURES BASF SE (DE) 2012-01-18 EP claimed
EP-1820793-B1 Process of stabilization of nucleic acids in biological materials QIAGEN GMBH (DE) 2011-09-14 EP claimed
EP-2292837-A1 Triazinylaminostilbene disulphonic acid mixtures BASF SE (DE) 2011-03-09 EP claimed
US-7585333-B2 Fluorescent whitening agent, for whitening synthetic or natural organic materials, especially paper and for the fluorescent whitening and improvement of sun protection factors of textile materials CIBA SPECIALTY CHEMICALS CORPORATION (US) 2009-09-08 US claimed
US-20080307585-A1 Fluorescent whitening agent, for whitening synthetic or natural organic materials, especially paper and for the fluorescent whitening and improvement of sun protection factors of textile materials CIBA SPECIALTY CHEMICALS CORP. 2008-12-18 US claimed
US-20050203221-A1 Whitening pigments CIBA SPECIALTY CHEMICALS CORP. 2005-09-15 US claimed
US-8920781-B2 Carrier particles for use in dry powder inhalers VECTURA LIMITED (GB) 2014-12-30 US disclosed
US-8269037-B2 Absorption medium for removing acid gases which comprises amino acid and acid promoter BASF SE (DE) 2012-09-18 US disclosed
EP-2449488-A1 METHOD FOR NORMALIZATION IN METABOLOMICS ANALYSIS METHODS WITH ENDOGENOUS REFERENCE METABOLITES BIOCRATES Life Sciences AG (AT) 2012-05-09 EP disclosed
EP-1520073-B1 TRIAZINNYLAMINOSTILBENE DISULPHONIC ACID MIXTURES BASF SE (DE) 2012-01-18 EP disclosed
EP-2407540-A1 Method for purifying a target nucleic acid Qiagen GmbH (DE) 2012-01-18 EP disclosed
US-8034166-B2 Carbon dioxide absorbent requiring less regeneration energy BASF SE (DE) 2011-10-11 US disclosed
WO-2011086195-A1 METHOD FOR ISOLATING SMALL RNA QIAGEN GMBH (DE) 2011-07-21 WO disclosed
US-7718163-B2 Includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler; an inhalant includes crystalline milk sugar carrier,leucine additive and beclomethasone dipropionate inhalant VECTURA LIMITED (01696917) (GB) 2010-05-18 US disclosed
US-7011818-B2 Carrier particles for use in dry powder inhalers VECTURA LIMITED (GB) 2006-03-14 US disclosed
US-20060029552-A1 Includes additive material on the surfaces of the carrier particles to promote the release of the active particles from the carrier particles on actuation of the inhaler; an inhalant includes crystalline milk sugar carrier,leucine additive and beclomethasone dipropionate inhalant VECTURA LIMITED (GB) 2006-02-09 US disclosed
US-20050203221-A1 Whitening pigments CIBA SPECIALTY CHEMICALS CORP. 2005-09-15 US disclosed
US-20030170183-A1 Promotes the release of the active particles from the carrier particles on actuation of the inhaler; efficiency VECTURA LIMITED (GB) 2003-09-11 US disclosed
US-6521260-B1 Magnesium stearate additive material being on the surfaces of the carrier particles VECTURA LIMITED (GB) 2003-02-18 US disclosed
US-5134073-A Culture product of zoogloea ramigera DEGUSSA AKTIENGESELLSCHAFT (DE) 1992-07-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050203221-A1 Whitening pigments YTHDC1, TRPC1, AOC1 SLC7A5 894/4885SLC1A2 3382/4885SLC1A3 3010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.