Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL36472 | 0.89 | ESR1 (0.43) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| SCHEMBL29359879 | 0.89 | ESR1 (0.43) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| SCHEMBL8890931 | 0.87 | ESR1 (0.41) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| SCHEMBL28885893 | 0.83 | ESR1 (0.39) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| Hydroquinone SCHEMBL7168896 | 0.78 | LMNA (0.40) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| Pyrogallol SCHEMBL6035335 | 0.78 | TRPA1 (0.48) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| Benzoquinone SCHEMBL28375317 | 0.78 | ESR1 (0.35) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| SCHEMBL30027143 | 0.78 | ALDH1A1 (0.48) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| SCHEMBL70068 | 0.78 | ALDH1A1 (0.48) | ESR1ALDH1A1ALOX15HSD17B10TDP1 | |
| Butylated Hydroxytoluene SCHEMBL1679703 | 0.74 | SMN1; SMN2 (0.62) | ESR1ALDH1A1ALOX15HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116124933-A | Biological analysis method for measuring content of lysophosphatidic acid C18:2 in human plasma | 苏州旭辉检测有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-116124933-A | Biological analysis method for measuring content of lysophosphatidic acid C18:2 in human plasma | 苏州旭辉检测有限公司 | 2023-05-16 | — | — | CN | disclosed |