Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 1/20 | 0.54 |
| ▸ | CCNH | P51946 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 4/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.53 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.53 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30171056 | 1.00 | FLT3 (0.60) | FLT3MKNK1MKNK2CDK7CCNH | |
| SCHEMBL3250780 | 0.89 | CDK1 (0.69) | FLT3CDK1CCNB1CCNB2CCNB3 | |
| SCHEMBL29001472 | 0.84 | FLT3 (0.61) | FLT3MKNK1MKNK2CDK7CCNH | |
| SCHEMBL7467183 | 0.84 | FLT3 (0.60) | FLT3MKNK1MKNK2CDK1CCNB1 | |
| SCHEMBL3255323 | 0.81 | NUDT1 (0.54) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL31588329 | 0.80 | CCNB2 (0.76) | FLT3MKNK1MKNK2CDK1CCNB1 | |
| SCHEMBL144954 | 0.80 | CCNB2 (0.76) | FLT3MKNK1MKNK2CDK1CCNB1 | |
| SCHEMBL4510383 | 0.78 | FLT3 (0.64) | FLT3MKNK1MKNK2CDK1CCNB1 | |
| SCHEMBL4517500 | 0.77 | FLT3 (0.60) | FLT3MKNK1MKNK2CDK7CCNH | |
| SCHEMBL140969 | 0.77 | CCNB2 (0.64) | FLT3MKNK1MKNK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115745968-B | 4- (4-indolylpyrimidin-2-ylamino) -N' -benzylidene benzoyl hydrazine derivative, preparation method and application | 浙江师范大学行知学院 | 2023-12-22 | — | — | CN | claimed |
| CN-115745968-A | 4- (4-indolyl pyrimidine-2-ylamino) -N' -benzylidene benzoyl hydrazine derivative and preparation method and application thereof | 浙江师范大学行知学院 | 2023-03-07 | — | — | CN | claimed |
| CN-115745968-B | 4- (4-indolylpyrimidin-2-ylamino) -N' -benzylidene benzoyl hydrazine derivative, preparation method and application | 浙江师范大学行知学院 | 2023-12-22 | — | — | CN | disclosed |
| CN-115745968-B | 4- (4-indolylpyrimidin-2-ylamino) -N' -benzylidene benzoyl hydrazine derivative, preparation method and application | 浙江师范大学行知学院 | 2023-12-22 | — | — | CN | disclosed |
| CN-115745968-A | 4- (4-indolyl pyrimidine-2-ylamino) -N' -benzylidene benzoyl hydrazine derivative and preparation method and application thereof | 浙江师范大学行知学院 | 2023-03-07 | — | — | CN | disclosed |
| CN-115745968-A | 4- (4-indolyl pyrimidine-2-ylamino) -N' -benzylidene benzoyl hydrazine derivative and preparation method and application thereof | 浙江师范大学行知学院 | 2023-03-07 | — | — | CN | disclosed |