Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 8/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.59 |
| ▸ | CDK1 | P06493 | 4/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.59 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.59 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | PRKACG | P22612 | 1/20 | 0.54 |
| ▸ | PRKACB | P22694 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL144954 | 0.87 | CCNB2 (0.76) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL31588329 | 0.87 | CCNB2 (0.76) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL4510383 | 0.85 | FLT3 (0.64) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL4517500 | 0.84 | FLT3 (0.60) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL29001476 | 0.84 | FLT3 (0.60) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL30171056 | 0.84 | FLT3 (0.60) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL140969 | 0.81 | CCNB2 (0.64) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL29001472 | 0.81 | FLT3 (0.61) | FLT3MKNK1MKNK2RETCCNB2 | |
| SCHEMBL7474541 | 0.80 | RET (0.50) | RETCCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL23624996 | 0.80 | FLT3 (0.58) | FLT3MKNK1MKNK2RETCCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |