Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 18/20 | 0.83 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904472 | 0.91 | PYGL (1.00) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL6509535 | 0.82 | PYGL (0.83) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL6516959 | 0.81 | PYGL (0.66) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL12305513 | 0.80 | PYGL (0.67) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL4699966 | 0.77 | PYGL (0.72) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL18500908 | 0.77 | ALDH1A1 (0.74) | PYGL | |
| SCHEMBL4699957 | 0.76 | PYGL (0.71) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL12305525 | 0.76 | PYGL (0.62) | PYGLHDAC1HDAC8HDAC6 | |
| SCHEMBL6066438 | 0.76 | MEN1 (0.59) | HDAC1HDAC8HDAC6TTR | |
| SCHEMBL13964448 | 0.76 | HDAC1 (0.72) | PYGLHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497262-B1 | ACYL-4-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-08-04 | — | — | EP | disclosed |
| EP-1497263-B1 | ACYL-3-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-7223796-B2 | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-29 | — | — | US | disclosed |
| US-7078404-B2 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-18 | — | — | US | disclosed |
| EP-1497263-A1 | ACYL-3-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | Aventis Pharma Deutschland GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| EP-1497262-A1 | ACYL-4-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | Aventis Pharma Deutschland GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| US-20040077716-A1 | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-04-22 | — | — | US | disclosed |
| US-20030216370-A1 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2003-11-20 | — | — | US | disclosed |
| WO-2003084923-A1 | ACYL-3-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-16 | — | — | WO | disclosed |
| WO-2003084922-A1 | ACYL-4-CARBOXYPHENYLUREA DERIVATIVES, METHOD FOR PRODUCTION AND USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216370-A1 | Acyl-3-carboxyphenylurea derivatives, processes for preparing them and their use | CPS1, AGPAT2, GLS | PYGL 569/4885HDAC1 3536/4885HDAC8 4261/4885 |
| US-20040077716-A1 | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use | DPP4, CPS1, GLS | PYGL 393/4885HDAC1 3279/4885HDAC8 4072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.