Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ATF1 | P18846 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | GLP1R | P43220 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29990333 | 1.00 | ALDH1A1 (0.33) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL22043384 | 0.79 | LMNA (0.30) | POLB | |
| SCHEMBL17964135 | 0.78 | HTT (0.43) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL29721809 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2PLAUKDM4EPOLB | |
| SCHEMBL28952489 | 0.75 | ALDH1A1 (0.33) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL25584917 | 0.75 | GLP1R (0.37) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL26177172 | 0.75 | ALDH1A1 (0.39) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL17963955 | 0.75 | TRPV4 (0.42) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL15674757 | 0.75 | PLAU (0.42) | ALDH1A1ATF1NFKB1GLP1RSMN1; SMN2 | |
| SCHEMBL363834 | 0.75 | ALDH1A1 (0.37) | ALDH1A1ATF1NFKB1GLP1RPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597339-A | Aryl 3-oxo-piperazine carboxamides and heteroaryl 3-oxo-piperazine carboxamides as NAV1.8 inhibitors | 默沙东有限责任公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-116134018-A | 2-oxoimidazolidine-4-carboxamide as NAV1.8 inhibitor | 默沙东有限责任公司 | 2023-05-16 | — | — | CN | disclosed |