SCHEMBL29005683

SCHEMBL29005683

CC(C)(C)OC(=O)n1ccc2cc(F)cc(C#N)c21

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ACLY P53396 1/20 0.41
GPR119 Q8TDV5 4/20 0.37
TRPA1 O75762 1/20 0.36
BUB1 O43683 1/20 0.36
NR3C2 P08235 2/20 0.35
HSP90AA1 P07900 1/20 0.35
HSP90AB1 P08238 1/20 0.35
AR P10275 6/20 0.35
ROCK2 O75116 1/20 0.33
XDH P47989 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25313031 0.83 ACLY (0.41) ACLYGPR119TRPA1BUB1NR3C2
SCHEMBL19100666 0.82 ACLY (0.44) ACLYGPR119BUB1HSP90AA1HSP90AB1
SCHEMBL30310705 0.80 ACLY (0.43) ACLYGPR119BUB1NR3C2HSP90AA1
SCHEMBL24021144 0.80 ACLY (0.43) ACLYGPR119BUB1NR3C2HSP90AA1
SCHEMBL29066884 0.80 ACLY (0.39) ACLYGPR119TRPA1BUB1HSP90AA1
SCHEMBL29005699 0.77 GPR119 (0.33) GPR119TRPA1NR3C2AR
SCHEMBL31358036 0.77 GPR119 (0.35) GPR119TRPA1AR
SCHEMBL18585317 0.76 ACLY (0.36) ACLYGPR119BUB1HSP90AA1HSP90AB1
SCHEMBL819797 0.74 PIK3CD (0.46) ACLYBUB1HSP90AA1HSP90AB1
SCHEMBL18805035 0.74 PIK3CD (0.46) ACLYBUB1HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115996926-A Indole compounds as androgen receptor modulators 尼多生物科学有限公司 2023-04-21 CN disclosed