Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 5/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.54 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.54 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.54 |
| ▸ | ECE1 | P42892 | 3/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CCR9 | P51686 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2892433 | 0.89 | ECE1 (0.56) | KCNQ3KCNQ2KCNE1KCNQ1ECE1 | |
| SCHEMBL2895485 | 0.86 | MAPT (0.49) | KCNQ3KCNQ2CCR2HIF1AEPAS1 | |
| SCHEMBL27808797 | 0.84 | CCR2 (0.44) | ECE1CCR2HIF1AEPAS1FLT1 | |
| SCHEMBL1053339 | 0.81 | TRPV1 (0.45) | ECE1CCR2HIF1AEPAS1FLT1 | |
| SCHEMBL3575898 | 0.80 | RAB9A (0.51) | CCR2HIF1AEPAS1FLT1KDR | |
| SCHEMBL2900643 | 0.79 | MAPT (0.49) | KCNQ3KCNQ2CCR2HIF1AEPAS1 | |
| SCHEMBL2894997 | 0.79 | CCR2 (0.71) | CCR2PPARGCCR9 | |
| SCHEMBL2900723 | 0.78 | ECE1 (0.58) | KCNQ3KCNQ2KCNE1KCNQ1ECE1 | |
| SCHEMBL27779932 | 0.78 | CCR2 (0.57) | CCR2HIF1AEPAS1PPARGJAK2 | |
| SCHEMBL27829310 | 0.77 | CCR2 (0.44) | CCR2HIF1AEPAS1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586573-B2 | N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof | SANOFI (FR) | 2013-11-19 | — | — | US | disclosed |
| US-20100286119-A1 | N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2010-11-11 | — | — | US | disclosed |
| US-7786104-B2 | N-(aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2010-08-31 | — | — | US | disclosed |
| EP-2049525-B1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI AVENTIS (FR) | 2009-12-30 | — | — | EP | disclosed |
| US-20090156573-A1 | N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof | SANOFI-AVENTIS (FR) | 2009-06-18 | — | — | US | disclosed |
| EP-2049525-A1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATION THEREOF | Sanofi-Aventis (FR) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008015335-A1 | N-(AMINOHETEROARYL)-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286119-A1 | N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof | IDO1, IDO2, TPH1 | KCNQ3 1390/4885KCNQ2 2051/4885KCNE1 1865/4885 |
| US-20090156573-A1 | N-(Aminoheteroaryl)-1H-indole-2-carboxamide derivatives, and preparation and therapeutic application thereof | IDO1, IDO2, TPH1 | KCNQ3 1390/4885KCNQ2 2051/4885KCNE1 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.