Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 4/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2900298 | 0.99 | CHRNA7 (0.39) | CHRNA7HTR3AGRIN1GRIN2BCYP3A4 | |
| SCHEMBL5358060 | 0.77 | CHRNA7 (0.39) | CHRNA7HTR3ACHRM2CHRM4CHRM5 | |
| SCHEMBL2899831 | 0.77 | CYP2A6 (0.39) | CHRNA7HTR3ACYP2E1CYP2A6CYP2B6 | |
| SCHEMBL5358073 | 0.76 | CHRNA7 (0.36) | CHRNA7HTR3ACHRM2CHRM4CHRM5 | |
| SCHEMBL2895959 | 0.76 | CHRM2 (0.41) | CHRNA7HTR3ACHRM2CHRM4CHRM5 | |
| SCHEMBL5350554 | 0.75 | CHRNA7 (0.38) | CHRNA7HTR3A | |
| SCHEMBL5353379 | 0.75 | KDM4E (0.43) | CHRNA7HTR3ACYP2C9ALDH1A1CYP1A2 | |
| SCHEMBL5355916 | 0.75 | CHRNA7 (0.38) | CHRNA7HTR3AMEN1ALDH1A1LMNA | |
| SCHEMBL6192934 | 0.75 | NPC1 (0.57) | CHRNA7HTR3AMAOBMEN1ALDH1A1 | |
| SCHEMBL5359078 | 0.75 | HTR3A (0.45) | CHRNA7HTR3ACHRNB4CHRNA3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100286128-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-11-11 | — | — | US | claimed |
| EP-2190846-A1 | 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-06-02 | — | — | EP | claimed |
| WO-2009024515-A1 | 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-02-26 | — | — | WO | claimed |
| US-20100286128-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-11-11 | — | — | US | disclosed |
| EP-2190846-A1 | 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024515-A1 | 1,4-DIAZA-BICYCL0(3.2.2)N0NYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE- RECEPTOR LIGANDS | NEUROSEARCH A/S (DK) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286128-A1 | 1,4-DIAZA-BICYCLO[3.2.2]NONYL PYRIMIDINYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE-RECEPTOR LIGANDS | CHRNA2, CHRNA5, CHRNA3 | CHRNA7 5/4885HTR3A 144/4885GRIN1 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.