SCHEMBL29009754

SCHEMBL29009754

CCC(C(=O)O)c1ccc(C(F)F)cc1C

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 16/20 0.45
AKR1C2 P52895 16/20 0.45
AKR1C1 Q04828 3/20 0.42
PTGS1 P23219 2/20 0.42
AKR1B10 O60218 2/20 0.41
AKR1C4 P17516 2/20 0.41
PTGS2 P35354 1/20 0.39
GRM1 Q13255 2/20 0.36
MEN1 O00255 1/20 0.36
CYP1A2 P05177 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29009885 0.80 AKR1C3 (0.40) AKR1C3AKR1C2AKR1C1PTGS1AKR1C4
SCHEMBL510474 0.80 SRC (0.44) AKR1C3AKR1C2AKR1C1PTGS1GRM1
SCHEMBL16744658 0.78 HTT (0.39) AKR1C3AKR1C2AKR1C1PTGS1AKR1B10
SCHEMBL1357313 0.78 HTT (0.39) AKR1C3AKR1C2AKR1C1PTGS1AKR1B10
SCHEMBL8169224 0.78 HTT (0.39) AKR1C3AKR1C2AKR1C1PTGS1AKR1B10
SCHEMBL509516 0.78 AKR1C3 (0.43) AKR1C3AKR1C2AKR1C1PTGS1PTGS2
SCHEMBL3171360 0.78 GRM1 (0.38) AKR1C3AKR1C2AKR1C1PTGS1AKR1B10
SCHEMBL29010070 0.76 AKR1C3 (0.44) AKR1C3AKR1C2AKR1C1PTGS1PTGS2
SCHEMBL2656910 0.75 AKR1C3 (0.55) AKR1C3AKR1C2AKR1C1PTGS1AKR1B10
SCHEMBL6833039 0.74 MRGPRX4 (0.40) AKR1C3AKR1C2AKR1C1PTGS1GRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116209433-A Small molecule albumin binding agents 俄勒冈健康科学大学 2023-06-02 CN disclosed