SCHEMBL29011897

SCHEMBL29011897

COc1cc(O)c(C(=O)/C=C/c2ccccc2)cc1C

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.64
NPC1 O15118 2/20 0.64
RAB9A P51151 2/20 0.64
ATM Q13315 2/20 0.64
ABCG2 Q9UNQ0 2/20 0.64
LMNA P02545 1/20 0.64
RECQL P46063 1/20 0.64
L3MBTL1 Q9Y468 1/20 0.64
CYP3A4 P08684 3/20 0.63
CYP1A2 P05177 2/20 0.63
CYP2D6 P10635 1/20 0.63
CYP2C9 P11712 1/20 0.63
CYP2C19 P33261 1/20 0.63
KMT2A Q03164 4/20 0.60
MEN1 O00255 3/20 0.60
CYP1A1 P04798 1/20 0.60
CYP1B1 Q16678 1/20 0.60
NPSR1 Q6W5P4 2/20 0.59
KCNA3 P22001 1/20 0.59
ACHE P22303 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30000665 0.90 CYP1A2 (0.76) MAPTNPC1RAB9AATMABCG2
SCHEMBL31233236 0.90 CYP1A2 (0.76) MAPTNPC1RAB9AATMABCG2
SCHEMBL29011937 0.89 MAPT (0.67) MAPTNPC1RAB9AATMABCG2
SCHEMBL29011908 0.87 ACHE (0.76) MAPTABCG2LMNAL3MBTL1CYP3A4
SCHEMBL30000672 0.86 MAPT (0.65) MAPTNPC1RAB9AATMABCG2
SCHEMBL5088653 0.85 MAPT (0.62) MAPTNPC1RAB9AATMABCG2
SCHEMBL5088647 0.85 MAPT (0.62) MAPTNPC1RAB9AATMABCG2
SCHEMBL29011938 0.84 MAPT (0.63) MAPTNPC1RAB9AATMABCG2
SCHEMBL25208067 0.83 CYP3A4 (0.65) MAPTNPC1RAB9AATMABCG2
SCHEMBL17786438 0.81 MAPT (0.57) MAPTNPC1RAB9AATMABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116023247-A 2-propylene-1 ketone compound and preparation method and application thereof 暨南大学 2023-04-28 CN claimed
CN-116023247-A 2-propylene-1 ketone compound and preparation method and application thereof 暨南大学 2023-04-28 CN disclosed