SCHEMBL29011908

SCHEMBL29011908

COc1cc(O)c(C(=O)/C=C/c2ccc(F)cc2)cc1C

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.76
BACE1 P56817 3/20 0.76
CTSL P07711 2/20 0.65
CXCL12 P48061 1/20 0.58
TUBB4A P04350 1/20 0.56
TUBB P07437 1/20 0.56
TUBA3C P0DPH7 1/20 0.56
TUBA1B P68363 1/20 0.56
TUBA4A P68366 1/20 0.56
TUBB4B P68371 1/20 0.56
TUBB3 Q13509 1/20 0.56
TUBB2A Q13885 1/20 0.56
TUBB8 Q3ZCM7 1/20 0.56
TUBA3E Q6PEY2 1/20 0.56
TUBA1A Q71U36 1/20 0.56
TUBA1C Q9BQE3 1/20 0.56
TUBB6 Q9BUF5 1/20 0.56
TUBB2B Q9BVA1 1/20 0.56
TUBB1 Q9H4B7 1/20 0.56
MAPT P10636 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25239854 0.91 ACHE (0.81) ACHEBACE1CTSLCXCL12TUBB4A
SCHEMBL29011898 0.90 CTSL (0.68) ACHEBACE1CTSLCXCL12TUBB4A
SCHEMBL29011897 0.87 MAPT (0.64) ACHEBACE1MAPTNPSR1L3MBTL1
SCHEMBL29011899 0.85 MAPT (0.62) ACHEBACE1CTSLMAPTNPSR1
SCHEMBL25223485 0.81 CYP3A4 (0.66) ACHEBACE1CXCL12MAPTABCG2
SCHEMBL30745430 0.81 ACHE (0.67) ACHEBACE1CTSLCXCL12TUBB4A
SCHEMBL30745488 0.80 ACHE (0.65) ACHEBACE1CTSLCXCL12TUBB4A
SCHEMBL25202393 0.79 CTSL (1.00) ACHEBACE1CTSLCXCL12MAPT
SCHEMBL25208750 0.79 CTSL (1.00) CTSLMAPTL3MBTL1ABCG2CYP3A4
SCHEMBL14698560 0.79 TUBB1 (0.68) ACHETUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116023247-A 2-propylene-1 ketone compound and preparation method and application thereof 暨南大学 2023-04-28 CN claimed
CN-116023247-A 2-propylene-1 ketone compound and preparation method and application thereof 暨南大学 2023-04-28 CN disclosed