Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29011970 | 0.88 | TRPC6 (0.38) | TRPC6KDM4E | |
| SCHEMBL21045747 | 0.83 | TRPC6 (0.50) | TRPC6GPR35ALOX15ASPHKDM4E | |
| SCHEMBL18009392 | 0.79 | GPR35 (0.49) | GPR35ALOX15ASPHKDM4EKDM8 | |
| SCHEMBL29368707 | 0.79 | GPR35 (0.49) | GPR35ALOX15ASPHKDM4EKDM8 | |
| SCHEMBL21045923 | 0.78 | TRPC6 (0.55) | TRPC6GPR35ALOX15ASPHKDM4E | |
| SCHEMBL21045936 | 0.78 | TRPC6 (0.55) | TRPC6GPR35ALOX15ASPHKDM4E | |
| SCHEMBL21045922 | 0.78 | TRPC6 (0.55) | TRPC6GPR35ALOX15ASPHKDM4E | |
| SCHEMBL71748 | 0.77 | KMO (0.45) | TRPC6GPR35ALOX15ASPHKDM4E | |
| SCHEMBL21045622 | 0.74 | TRPC6 (0.52) | TRPC6GPR35ALOX15ASPHKDM4E | |
| SCHEMBL30439836 | 0.74 | TRPC6 (0.52) | TRPC6GPR35ALOX15ASPHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |