Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | ASPH | Q12797 | 3/20 | 0.58 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24510117 | 0.86 | KDM4E (0.41) | KDM4EASPHKDM8MAPK1LMNA | |
| SCHEMBL29743774 | 0.86 | KDM4E (0.41) | KDM4EASPHKDM8MAPK1LMNA | |
| SCHEMBL27164886 | 0.86 | KDM4E (0.53) | KDM4EASPHKDM8MAPK1LMNA | |
| SCHEMBL18009392 | 0.83 | GPR35 (0.49) | KDM4EASPHKDM8MAPK1GPR35 | |
| SCHEMBL29368707 | 0.83 | GPR35 (0.49) | KDM4EASPHKDM8MAPK1GPR35 | |
| SCHEMBL28979056 | 0.82 | KDM4E (0.46) | KDM4EASPHKDM8MAPK1LMNA | |
| SCHEMBL9568767 | 0.80 | KDM4E (0.50) | KDM4EASPHKDM8MAPK1GPR35 | |
| SCHEMBL1425220 | 0.80 | GPR35 (0.50) | KDM4EASPHKDM8MAPK1GPR35 | |
| SCHEMBL21045825 | 0.80 | HTT (0.49) | KDM4EASPHKDM8MAPK1HTT | |
| SCHEMBL30028650 | 0.80 | GPR35 (0.50) | KDM4EASPHKDM8MAPK1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527078-B | Pyridinecarbonyl derivatives and their therapeutic use as TRPC6 inhibitors | 勃林格殷格翰国际公司 | 2023-06-02 | — | — | CN | disclosed |