Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | ASPH | Q12797 | 4/20 | 0.50 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | DDT | P30046 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17674991 | 0.88 | KDM4E (0.46) | KDM4EASPHKDM8ALDH1A1HPGD | |
| SCHEMBL9318874 | 0.85 | KDM4E (0.55) | KDM4EASPHKDM8ALDH1A1HPGD | |
| SCHEMBL29368707 | 0.85 | GPR35 (0.49) | KDM4EASPHKDM8ALDH1A1GPR35 | |
| SCHEMBL18009392 | 0.85 | GPR35 (0.49) | KDM4EASPHKDM8ALDH1A1GPR35 | |
| SCHEMBL17675046 | 0.82 | KDM4E (0.41) | KDM4EASPHKDM8GPR35ALOX15 | |
| SCHEMBL25235667 | 0.81 | KDM4E (0.47) | KDM4EASPHKDM8ALDH1A1HPGD | |
| SCHEMBL4981534 | 0.81 | NNMT (0.53) | KDM4EALDH1A1HPGDLCKFYN | |
| SCHEMBL3527742 | 0.81 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDLCKFYN | |
| SCHEMBL5008438 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDLCKFYN | |
| SCHEMBL11590515 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDLCKFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548883-A1 | Substituted pyridine-N-oxides, process for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-30 | — | — | EP | disclosed |