Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28917593 | 0.84 | HTT (0.47) | MAOBSQORRORCALDH1A1HTT | |
| SCHEMBL24873214 | 0.81 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA3MAOB | |
| SCHEMBL30112435 | 0.81 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA3MAOB | |
| SCHEMBL29013156 | 0.80 | FEN1 (0.45) | RORCLTA4HMAPK14 | |
| SCHEMBL25935014 | 0.80 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA3MAOB | |
| SCHEMBL859892 | 0.80 | RORC (0.39) | GABRG2GABRB3GABRA5GABRA3MAOB | |
| SCHEMBL1386543 | 0.80 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA3MAOB | |
| SCHEMBL4705 | 0.78 | LOXL2 (0.47) | GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28899812 | 0.77 | KDM1A (0.43) | MAOBSQORPTGER1RORCALDH1A1 | |
| SCHEMBL29021274 | 0.75 | APP (0.47) | SQORRORCLTA4HMAPK14PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116323580-A | Conjugated degradation (EGFR) of EGFR inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |