SCHEMBL29014341

SCHEMBL29014341

COC(=O)c1ccc(C)cc1F.COC(=O)c1ccc2ccccc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
ALDH1A1 P00352 6/20 0.49
KMT2A Q03164 1/20 0.49
KDM4E B2RXH2 4/20 0.48
GLA P06280 2/20 0.48
GAA P10253 2/20 0.48
HPGD P15428 2/20 0.48
ATM Q13315 2/20 0.48
SLC6A2 P23975 1/20 0.47
SLC6A4 P31645 1/20 0.47
SLC6A3 Q01959 1/20 0.47
PLAU P00749 1/20 0.46
ALOX12 P18054 1/20 0.46
MAPT P10636 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
HSD17B10 Q99714 1/20 0.46
KAT6A Q92794 1/20 0.46
TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL507988 0.83 CYP46A1 (0.53) NPC1RAB9AALDH1A1KDM4EGLA
SCHEMBL1003761 0.81 KDM4E (0.62) NPC1RAB9AALDH1A1KDM4ESLC6A2
SCHEMBL523320 0.80 KDM4E (0.62) ALDH1A1KMT2AKDM4EGLAGAA
Hydrochloric Acid SCHEMBL15414839 0.80 KDM4E (0.60) NPC1RAB9AALDH1A1KDM4ESLC6A2
SCHEMBL3210145 0.80 TDP1 (0.64) NPC1RAB9AALDH1A1KMT2AKDM4E
SCHEMBL6414914 0.78 CYP2A6 (0.65) NPC1RAB9AALDH1A1KMT2AKDM4E
SCHEMBL28514499 0.77 KDM4E (0.57) NPC1RAB9AALDH1A1KDM4ESLC6A2
Boric Acid SCHEMBL28499454 0.77 KDM4E (0.57) NPC1RAB9AALDH1A1KDM4ESLC6A2
SCHEMBL18288017 0.76 ALOX15 (0.58) NPC1RAB9AALDH1A1KDM4ESLC6A2
SCHEMBL10900668 0.76 ALOX15 (0.58) NPC1RAB9AALDH1A1KDM4ESLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115160098-B Oxygen-containing compound deoxidization methylation method 中国科学院兰州化学物理研究所 2023-06-06 CN disclosed