Pyrimidine

Pyrimidine

SCHEMBL29014623

Cc1c[nH]c(=S)[nH]c1=O.c1cncnc1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ATAD2 Q6PL18 2/20 0.46
KDM3B Q7LBC6 1/20 0.40
UBE2N P61088 1/20 0.39
KMT2A Q03164 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
HDAC8 Q9BY41 1/20 0.36
FFAR3 O14843 1/20 0.32
HCAR2 Q8TDS4 1/20 0.32
MEN1 O00255 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
NSD2 O96028 1/20 0.31
CASP6 P55212 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GAA P10253 1/20 0.31
GFER P55789 1/20 0.31
PIM1 P11309 1/20 0.31
PIM3 Q86V86 1/20 0.31
PIM2 Q9P1W9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25418259 0.85 ATAD2 (0.60) ATAD2KDM3BUBE2NKMT2ATDP1
SCHEMBL25450 0.85
SCHEMBL28216801 0.83 ATAD2 (0.58) ATAD2KDM3BUBE2NKMT2ATDP1
Thymine SCHEMBL535796 0.82 ATAD2 (0.70) ATAD2KMT2AMEN1GAA
Thymine SCHEMBL15174408 0.82 ATAD2 (0.70) ATAD2KMT2AMEN1GAA
Thymine SCHEMBL29232704 0.78 ATAD2 (0.76) ATAD2KDM3BUBE2NKMT2ATDP1
Thymine SCHEMBL18229756 0.76 ATAD2 (0.59) ATAD2GAA
SCHEMBL28211067 0.74 ATAD2 (0.47) ATAD2KDM3BUBE2NKMT2ATDP1
Thiouracil SCHEMBL4958659 0.72 TP53 (0.66) ATAD2KDM3BUBE2NKMT2ATDP1
SCHEMBL28216798 0.72 ATAD2 (0.46) ATAD2KDM3BUBE2NKMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116262917-A G-quadruplex-containing nucleic acids 成都凌泰氪生物技术有限公司 2023-06-16 CN disclosed