Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclobenzaprine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.82 |
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.82 |
| ▸ | HRH1 | P35367 | 7/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.82 |
| ▸ | HTR2B | P41595 | 6/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.82 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.82 |
| ▸ | DRD2 | P14416 | 5/20 | 0.82 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.82 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.82 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.82 |
| ▸ | DRD3 | P35462 | 5/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.82 |
| ▸ | HTR1A | P08908 | 4/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.82 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.82 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.82 |
| ▸ | RET | P07949 | 2/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclobenzaprine SCHEMBL7654526 | 0.91 | HRH1 (1.00) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL38527 | 0.91 | HRH1 (1.00) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL29520569 | 0.91 | HRH1 (1.00) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL41376 | 0.89 | LMNA (1.00) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL4964925 | 0.89 | LMNA (1.00) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL29350662 | 0.89 | LMNA (1.00) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL8892591 | 0.88 | HRH1 (0.82) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL4606463 | 0.88 | LMNA (0.97) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL1649752 | 0.88 | HRH1 (0.93) | HRH1SLC6A2HTR2BKCNH2CHRM2 | |
| Cyclobenzaprine SCHEMBL4441651 | 0.86 | SLC6A2 (0.78) | HRH1SLC6A2HTR2BKCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110177592-B | Inhaler and airflow adaptor for inhaler | 诺尔顿沃特福德有限公司 | 2023-03-31 | — | — | CN | disclosed |