Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyclobenzaprine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.93 |
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 0.93 |
| ▸ | LMNA | P02545 | 7/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.97 |
| ▸ | MEN1 | O00255 | 4/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.97 |
| ▸ | APEX1 | P27695 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 8/20 | 0.93 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.93 |
| ▸ | HTR2B | P41595 | 6/20 | 0.93 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.93 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.93 |
| ▸ | DRD2 | P14416 | 6/20 | 0.93 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.93 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.93 |
| ▸ | DRD3 | P35462 | 6/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.93 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclobenzaprine SCHEMBL29350662 | 0.98 | LMNA (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL4964925 | 0.98 | LMNA (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL41376 | 0.98 | LMNA (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL38527 | 0.97 | HRH1 (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL7654526 | 0.97 | HRH1 (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL29520569 | 0.97 | HRH1 (1.00) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL1649752 | 0.93 | HRH1 (0.93) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL17812812 | 0.90 | LMNA (0.85) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL17812696 | 0.89 | HRH1 (0.84) | LMNAPMP22MEN1KMT2AAPEX1 | |
| Cyclobenzaprine SCHEMBL29015268 | 0.88 | HRH1 (0.82) | LMNAPMP22MEN1KMT2AAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592410-B1 | METHODS AND DOSAGE FORMS WITH MODIFIED LAYER GEOMETRY | ALZA CORP (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1592410-A1 | METHODS AND DOSAGE FORMS WITH MODIFIED LAYER GEOMETRY | Alza Corporation (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20040197407-A1 | Methods and dosage forms with modified layer geometry | ALZA CORPORATION | 2004-10-07 | — | — | US | disclosed |
| US-20040166160-A1 | Methods and dosage forms with modified viscosity layers | ALZA CORPORATION | 2004-08-26 | — | — | US | disclosed |
| WO-2004071497-A1 | METHODS AND DOSAGE FORMS WITH MODIFIED LAYER GEOMETRY | ALZA CORPORATION (US) | 2004-08-26 | — | — | WO | disclosed |
| WO-2004064772-A2 | METHODS AND DOSAGE FORMS WITH MODIFIED VISCOSITY LAYERS | ALZA CORPORATION (US) | 2004-08-05 | — | — | WO | disclosed |