Sugi Predict

Sugi Predict / Compounds / SCHEMBL290192

SCHEMBL290192

SCHEMBL290192

CCc1cc(C(F)(C(F)(F)F)C(F)(F)C(F)(F)F)cc(C)c1NC(=O)c1ccc(C#N)c(NC(=O)c2ccc(C#N)cc2C)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RXFP1 Q9HBX9 2/20 0.36
▸ NR1H4 Q96RI1 1/20 0.35
▸ LRRK2 Q5S007 1/20 0.35
▸ KMT2A Q03164 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ MAPT P10636 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ ABCC9 O60706 1/20 0.33
▸ ABCC8 Q09428 1/20 0.33
▸ KCNJ11 Q14654 1/20 0.33
▸ KCNJ8 Q15842 1/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ CYP2C9 P11712 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ TMPRSS4 Q9NRS4 1/20 0.32
▸ BRAF P15056 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3708470 0.94 RXFP1 (0.34) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL289051 0.93 RXFP1 (0.39) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL3707902 0.92 RXFP1 (0.36) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL3709719 0.91 ABCC9 (0.37) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL31560030 0.91 RXFP1 (0.38) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL29362690 0.88 RXFP1 (0.37) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL29360734 0.88 KMT2A (0.39) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL3766659 0.88 RXFP1 (0.37) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL3703139 0.88 KMT2A (0.39) RXFP1NR1H4LRRK2KMT2AMEN1
SCHEMBL3704888 0.88 PDE5A (0.38) RXFP1NR1H4LRRK2KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106242998-B Use of 4-cyano-3-benzoylamino-N-phenyl-benzamides in pesticides 先正达参股股份有限公司 2021-11-05 — — CN disclosed
EP-2427427-B1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2013-12-25 — — EP disclosed
WO-2013092942-A1 USE OF AMINOBENZAMIDE DERIVATIVES FOR CONTROLLING ANIMAL PARASITES SYNGENTA PARTICIPATIONS AG (CH) 2013-06-27 — — WO disclosed
US-8431514-B2 4-cyano-3-benzoylamino-N-phenyl-benzamides for use in pest control SYNGENTA CROP PROTECTION LLC (US) 2013-04-30 — — US disclosed
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA CROP PROTECTION LLC (US) 2012-05-17 — — US disclosed
EP-2427427-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL Syngenta Participations AG (CH) 2012-03-14 — — EP disclosed
WO-2010127926-A1 4 -CYANO- 3 -BENZOYLAMINO-N- PHENYL-BENZAMIDES FOR USE IN PEST CONTROL SYNGENTA PARTICIPATIONS AG (CH) 2010-11-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122975-A1 4-CYANO-3-BENZOYLAMINO-N-PHENYL-BENZAMIDES FOR USE IN PEST CONTROL NISCH, AADAC, ACHE RXFP1 4237/4885NR1H4 2851/4885LRRK2 2121/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.